Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2406483 | Vaccine | 2009 | 4 Pages |
Abstract
To explore the best prime–boost regimen and evaluate the T-cellular response memory against HCV, we constructed two DNA vaccine candidates (pVRC-CE1E2 and pAAV-CE1E2) and two recombinant viruses (rTTV-E1E2 and rAAV-E1E2) and then assessed the immune response to different prime–boost patterns in BALB/c mice. The rTTV-E1E2 boosted the immune response to HCV DNA vaccine prime significantly, and the inverted terminal repeat sequence harboring DNA construct PAAV-CE1E2 was the best prime agent in this study. Our study provides new information for both the prime–boost regimen and long-term T-cell response for HCV vaccine development.
Keywords
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Authors
Yao Deng, Ke Zhang, Wenjie Tan, Yue Wang, Hong Chen, Xiaobing Wu, Li Ruan,