Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2406513 | Vaccine | 2008 | 8 Pages |
Abstract
SummaryImmunization of BALB/c mice with a DNA vaccine encoding the nucleosomal histones from Leishmania infantum resulted in a complete failure of protection against visceral leishmaniosis (VL), whereas the adoptive transfer of bone marrow-derived dendritic cells pulsed with the same pathoantigens plays an essential role in controlling parasite growth in half of the cases. Reduction of the visceral parasite burden seems to be related to low persistence of regulatory T-cells in the spleen from vaccinated mice. These results provide clues for the optimization of this vaccine strategy with the four Leishmania nucleosomal histones against L. infantum infection.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Javier Carrión, Cristina Folgueira, Carlos Alonso,