Evidence for correlation between the intensities of adjuvant effects and NOD2 activation by monomeric, dimeric and lipophylic derivatives of N-acetylglucosaminyl-N-acetylmuramyl peptides

On the whole, comparison of the adjuvanticity in vivo and the NOD2 activation in vitro revealed a clear correlation between the two responses. These findings confirm the view that NOD2 pathway activation should account, at least in part, for the adjuvant effects of these compounds.