Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2406824 | Vaccine | 2009 | 6 Pages |
Abstract
This study documents rotavirus strains causing severe disease in Australian children during the pre-vaccine era. During the period 1997–2007, rotavirus strains from national multi-centre hospital-based surveillance in Australia were analysed for G and P types. G1P[8] was the dominant genotype identified during the 11-year study, with intermittent peaks associated with genotypes G2P[4], G3P[8] and G9P[8]. The results provide baseline information of the G and P genotypes causing disease in Australian children, and highlight the unpredictable changes in genotype incidence that can occur on both a local and national level. To be optimally effective, rotavirus vaccines must prevent disease caused by all common rotavirus genotypes.
Keywords
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Immunology
Authors
Carl D. Kirkwood, Karen Boniface, Nada Bogdanovic-Sakran, Paul Masendycz, Graeme L. Barnes, Ruth F. Bishop,