Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2407124 | Vaccine | 2008 | 5 Pages |
Abstract
Cellular immunity is indispensable for efficient protection against intracellular bacterial infection. CD4+ and CD8+ T cells specific for a variety of antigenic peptides derived from particular bacteria are induced after the infection. T cells recognizing different antigenic peptides have been speculated to have different functions in terms of the protective immunity. We here induced individual CD4+ T cells specific for each antigenic peptide derived from Listeria monocytogenes independently with DNA vaccines using gene gun bombardment and compared the CD4+ T-cell populations for their ability on the specific protective immunity against lethal listerial challenge and analyzed their characteristics.
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Authors
Toshi Nagata, Taiki Aoshi, Masato Uchijima, Yukio Koide,