Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2407151 | Vaccine | 2008 | 7 Pages |
Abstract
SummaryThis study compared: (1) Freund's complete adjuvant and CpG oligodeoxynucleotide (ODN) 2006 in water-in-oil emulsion as adjuvants; and (2) increasing doses of a recombinant ovalbumin-LHRH (ova-LHRH) fusion protein as an antigen for a contraceptive vaccine. Treatment groups (n = 8 heifers/group) were: one untreated control group; five groups receiving CpG ODN with different doses of ova-LHRH (1.5; 2.3; 3.4; 5.1; and 7.6 mg); and one group receiving 3.4 mg ova-LHRH in Freund's. Heifers were immunized at weeks 0 and 14. All vaccine treatments caused gonadal regression and estrus suppression. CpG ODN is a suitable replacement for Freund's for LHRH immunization.
Keywords
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Authors
Valéria A. Conforti, David M. de Avila, Nada S. Cummings, Ricardo Zanella, Kenny J. Wells, Hasan Ülker, Jerry J. Reeves,