Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2407214 | Vaccine | 2007 | 8 Pages |
Abstract
Vaccination against Hepatitis A virus (HAV) in Canada is currently targeted toward high-risk groups. However, universal vaccination has been adopted in several other countries with a similar disease burden. Here we develop an age-structured compartmental model of HAV transmission and vaccination in Canada to assess potential universal vaccination strategies. The model predicts that universal vaccination at age 1 (respectively 4, 9, 15), with phasing out of targeted vaccination, would reduce reported incidence by 60% (respectively 52, 36, 31%) and mortality attributable to HAV by 56% (respectively 45, 26, 25%), relative to continued targeted vaccination, over 80 years.
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Authors
C.T. Bauch, Arni S.R. Srinivasa Rao, B.Z. Pham, M. Krahn, V. Gilca, B. Duval, M.H. Chen, A.C. Tricco,