| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2407221 | Vaccine | 2007 | 9 Pages |
Abstract
The anti-PA IgG1, IgG2, IgG3, and IgG4 subclass responses to clinical anthrax and to different numbers of anthrax vaccine adsorbed (AVA, BioThrax®) injections were determined in a cross-sectional study of sera from 63 vaccinees and 13 clinical anthrax patients. The data show that both vaccination with three AVA injections and clinical anthrax elicit anti-PA IgG1, IgG2, and IgG3 subclass responses. An anti-PA IgG4 response was detected in AVA recipients after the fourth injection. The anthrax lethal toxin (LTx) neutralization efficacy of sera from recipients who received 4 to ≥10 AVA injections did not vary significantly in relation to changes in distribution of anti-PA IgG1 and IgG4 subclasses.
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Authors
V.A. Semenova, D.S. Schmidt, T.H. Taylor Jr., H. Li, E. Steward-Clark, S.D. Soroka, M.M. Ballard, C.P. Quinn,