| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2407226 | Vaccine | 2007 | 14 Pages |
Abstract
The present study evaluates immunogenicity and protection potency of a codon-optimized GRA1 DNA vaccine, wild type GRA1 DNA vaccine and an adjuvanted recombinant GRA1 protein vaccine candidate in BALB/c mice against lethal toxoplasmosis. Of the three GRA1 vaccines tested, the recombinant GRA1 protein vaccine results reveal significant increase in immune response and prolonged survival against acute toxoplasmosis compared to DNA vaccinations. Immune response and protection conferred by codon-optimized GRA1 DNA vaccine was slightly better than wild type GRA1 DNA vaccine.
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Authors
Mert Döşkaya, Mina Kalantari-Dehaghi, Craig M. Walsh, Elżbieta Hiszczyńska-Sawicka, D. Huw Davies, Philip L. Felgner, Liza S.Z. Larsen, Richard H. Lathrop, G. Wesley Hatfield, Jessica R. Schulz, Yüksel Gürüz, Frances Jurnak,