Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2407295 | Vaccine | 2008 | 11 Pages |
Abstract
SummaryProtection against Plasmodium falciparum sporozoite infection can be achieved by vaccination with the recombinant circumsporozoite protein-based vaccine RTS,S formulated with the AS02A Adjuvant System. Since this protection is only partial and wanes over time, we have developed a new RTS,S-based vaccine adjuvanted with AS01B. RTS,S/AS01B-induced high specific antibody titers and increased the frequency of mouse CD4+ and CD8+ T cells expressing IFN-γ, and of monkey CD4+ T cells expressing IL-2 and/or IFN-γ and/or TNF-α upon stimulation with vaccine antigens. Our data provides clear evidence that combining RTS,S antigen with a potent adjuvant induces strong humoral and cellular responses in vivo.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Pascal Mettens, Patrice M. Dubois, Marie-Ange Demoitié, Babak Bayat, Marie-Noëlle Donner, Patricia Bourguignon, V. Ann Stewart, D. Gray Heppner Jr., Nathalie Garçon, Joe Cohen,