Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2407528 | Vaccine | 2008 | 9 Pages |
Abstract
Atypical furunculosis caused by atypical Aeromonas salmonicida, is an emerging problem in farming of Atlantic cod (Gadus morhua) in Norway, and vaccines are needed. Atypical A. salmonicida comprises a heterogeneous group of bacteria differing in surface antigens such as the A-layer protein and lipopolysaccharides (LPS). Except for one of the experimental oil-adjuvanted whole cell vaccines based on various isolates they all resulted in moderate protection. No clear correlation between vaccine efficacies and the A-protein group or LPS type of the vaccine isolates was revealed, while a correlation between efficacy and the presence of cross-reacting LPS-specific antibodies is indicated.
Keywords
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Immunology
Authors
Vera Lund, Jan Arne Arnesen, Helene Mikkelsen, Kjersti Gravningen, Laura Brown, Merete B. Schrøder,