Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2407544 | Vaccine | 2008 | 6 Pages |
Abstract
The gene Bs-Ag3 enconding a antigen of 37Â kDa from Baylisascaris schroederi (giant panda isolates), as well as the recombinant Bs-Ag3, obtained by cloning and expression of the Bs-Ag3 gene in heterologous host Escherichia coli BL-21 (DE3), were used to evaluate their ability to induce immune protective responses in BALB/c mice against L3-challenge infection in a mouse-B. schroederi model. There was a significant reduction (62.91%) of mice vaccinated with rBs-Ag3 coupled with Freund's complete adjuvant (FCA) in recovery of challenged B. schroederi L3 compared with either controls or mice vaccinated with FCA alone. Our data indicate recombinant Bs-Ag3 may be a potential target as a vaccine antigen for giant panda ascariasis.
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Authors
Tao Wang, Guangzhi He, Guangyou Yang, Yuxiang Fei, Zhihe Zhang, Chengdong Wang, Zhi Yang, Jingchao Lan, Li Luo, Li Liu,