Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2408071 | Vaccine | 2007 | 10 Pages |
Abstract
A Semliki Forest virus (SFV) recombinant particle vaccine vector was constructed expressing the viral E1 and E2 envelope proteins of the RA27/3 vaccine strain of rubella virus. This vector induced high titres of antibody after intramuscular administration to Balb/C mice, both following initial vaccination and a boost 4 weeks later. This occurred for antibody as measured by ELISA and as measured by a latex agglutination test. However, co-administration of similar particles expressing the measles virus H protein and the mumps virus HN protein with the rubella protein expressing vector resulted in reduction of the anti-rubella immune response.
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Authors
Sara J. Callagy, Barbara J. Kelly, Marina N. Fleeton, Brian J. Sheahan, Sareen E. Galbraith, Gregory J. Atkins,