Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2408162 | Vaccine | 2007 | 8 Pages |
Abstract
The development of novel vaccines against Neisseria meningitidis recently gained momentum by the generation of penta-acylated lpxL1 LPS which has similar adjuvant activity, but reduced endotoxic activity as compared to hexa-acylated wild type (H44/76) LPS. We investigated the costimulation requirements for the adjuvant activity of both forms of LPS by immunizing CD28-, ICOS- and B7.1/2/ICOS-deficient mice. Both ICOS and CD28 appeared essential for optimal adjuvant activity of H44/76 LPS or lpxL1 LPS. Interestingly, ICOS-mediated costimulation predominates in the adjuvant activity of lpxL1 LPS, while both ICOS and CD28 are required for H44/76 LPS adjuvant activity.
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Authors
Miranda E.A.T. van Berkel, Elise H.R. Schrijver, Andries van Mourik, Kiki Tesselaar, Peter van der Ley, Liana Steeghs, Mariëtte A. Oosterwegel,