| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2408378 | Vaccine | 2008 | 5 Pages |
Abstract
Cattle which survive an infection with Theileria annulata become effectively immune to challenge with the same parasite strain, and are thought to be protected against a heterologous strain of the parasite. T-cells play a crucial role in both induction and maintenance of immunity to T. annulata. The generation of cytotoxic T lymphocytes (CTL) is closely related to the control of the infection – macroschizont-infected cells are killed in an MHC class I restricted manner. Any strain-specificity induced by immunisation is likely to be manifested by CTL. Besides CTLs, CD4+ T-cells also play an important role in protective immunity to T. annulata infection.
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Authors
Ulrike Seitzer, Jabbar Ahmed,