Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2408580 | Vaccine | 2005 | 8 Pages |
Abstract
We evaluated whether a non-adjuvanted vaccine derived from Chinese hamster ovary cells was capable of providing protection against woodchuck hepatitis virus (WHV). Three woodchucks were vaccinated with four 50-μg doses and challenged with a previously characterized virus isolate (WHV197). In all three animals, titre levels of antibodies against hepatitis B surface antigens (anti-HBs) exceeded 10 mIU/ml, peaking at 150 mIU/ml. Challenge resulted in productive acute infection in the two non-vaccinated woodchucks yet in none of the vaccinated woodchucks. In the vaccinated animals, there was evidence of abortive infection. The results demonstrate that a human vaccine is able to protect woodchucks from WHV infection.
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Authors
Claudio Argentini, Roberto Giuseppetti, Emilio D’Ugo, Valentina La Sorsa, Elena Tritarelli, Sara Orobello, Andrea Canitano, Reinhard Glück, Maria Rapicetta,