Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2408666 | Vaccine | 2006 | 4 Pages |
Abstract
The bioavailability of oseltamivir phosphate and oseltamivir carboxylate were assessed in healthy volunteers when delivered as a solution of the active pharmaceutical ingredient (API) compared with the commercial capsule formulation. The 90% confidence intervals (CIs) for the ratios of the two treatments (capsule versus solution) were within the reference region [0.80–1.25] for area under the curve (AUC0–infinity: [0.94–0.99]) and maximum observed plasma concentrations (Cmax: [0.93–1.08]). Thus, the two formulations were bioequivalent for oseltamivir carboxylate. For pandemic stockpiling of Tamiflu®, governments can therefore choose between the capsule formulation alone, the API alone, or quantities of both.
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Authors
M. Brewster, J.R. Smith, R. Dutkowski, R. Robson,