| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2408863 | Vaccine | 2007 | 9 Pages |
Abstract
Transcutaneous immunisation (TCI) using a skin patch is a non-invasive vaccination route relevant to mass vaccination against infectious diseases. This phase I/II clinical study, documents that TCI of human adult volunteers with the live-attenuated measles vaccine ROUVAX® is safe and poorly reactogenic. It promotes induction of measles-specific salivary IgA and a tendency to increased frequency of MV-specific IFNγ-producing T cells. However, in contrast to the subcutaneous route, TCI failed to evoke neutralising MV-specific serum antibodies. Thus, alternative delivery methods and/or devices providing optimal uptake by skin DC should be considered for live-attenuated virus vaccines, such as the measles vaccine.
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Authors
Nathalie Etchart, Ana Hennino, Martin Friede, Karima Dahel, Monique Dupouy, Catherine Goujon-Henry, Jean-François Nicolas, Dominique Kaiserlian,