Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2408885 | Vaccine | 2007 | 6 Pages |
Abstract
Although smallpox vaccine-associated myopericarditis has been reported, the risk of cardiac ischemic events remains uncertain. We identified personnel receiving the smallpox vaccination and compared them to a historical referent population. The rate of cardiac ischemia diagnoses in the 30 days following smallpox vaccination was 140.1 per 100,000 person-years, compared to 143.5 per 100,000 person-years in referent group (RR 1.0 [95% CI: 0.7-1.4]). The rate of cardiac ischemic events in vaccinees was 121.4 per 100,000 person-years before and 175.7 after adopting pre-vaccination cardiac screening (RR 1.4 [95% CI: 0.8-2.7]). Implementation of pre-vaccination cardiac risk factor screening was not associated with a reduction in cardiac events.
Keywords
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Immunology
Authors
Robert E. Eckart, Eric A. Shry, J. Edwin Atwood, John F. Brundage, Jenny C. Lay, Thomas F. Bateson, John D. Grabenstein,