| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2409006 | Vaccine | 2006 | 7 Pages |
Abstract
The effect of priming and boosting with pspA/EF5668 and purified recombinant PspA/EF5668 was examined. With this strategy CBA/N mice were protected against fatal challenge with Streptococcus pneumoniae EF5668. Anti-PspA antibody titers were elevated, and Western analysis with the immune serum demonstrated cross-reactivity with PspA from several different pneumococcal isolates, representing different PspA clades. Immune serum localized cross-reactive epitopes to the alpha-helical domain of PspA/Rx1 and PspA/EF5668. We demonstrated that DNA/protein prime-boost immunizations can enhance protective immunity against pneumococcal challenge.
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Immunology
Authors
Quincy C. Moore, Joseph R. Bosarge, Lisa R. Quin, Larry S. McDaniel,