Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2409040 | Vaccine | 2007 | 7 Pages |
Abstract
Paracoccidioides brasiliensis is the fungus agent of paracoccidioidomycosis, a chronic systemic disease prevalent in Latin America. The aim of the present work was to evaluate the protection elicited by the immunization of BALB/c mice with radioattenuated yeast cells of P. brasiliensis. The immunization promoted a long lasting protection against highly infective yeast forms of P. brasiliensis. A 99.5% decrease in CFUs recovery was verified 90 days post challenge. At the same time the levels of IgG2a and IFN-γ were high while a very low production of IL-10 and IL-5 was verified, suggesting that a Th1 pattern was dominant. This work shows the potential of radioattenuated yeast cells for the development of vaccines against fungi infections.
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Authors
Estefânia Mara do Nascimento Martins, Bernardo Sgarbi Reis, Viviane Cristina Fernandes, MÃriam Maria Silva Costa, Alfredo Miranda Goes, Antero Silva Ribeiro de Andrade,