Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2409143 | Vaccine | 2007 | 7 Pages |
Abstract
A DNA plasmid expressing both the influenza viral matrix protein (M1) and hemagglutinin (HA) (pHA/M1) as a potential vaccine candidate was investigated. Vaccination with pHA/M1 double insertion plasmids not only induced HA-specific protective antibodies, but also elicited HA and M1-specific CD8 T cell responses. Mice immunized with pHA/M1 dual expressing plasmid showed enhanced HA inhibition titer and increased CD69+ CD8α+ T cell response compared to groups that received either the vector or a mixture of both pHA and pM1 (pHA + pM1). Furthermore, pHA/M1 immunization resulted in improved protection against both homologous and heterologous challenges.
Keywords
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Immunology
Authors
Hang Xie, Teresa Liu, Hong Chen, Xiaoyuan Huang, Zhiping Ye,