Article ID Journal Published Year Pages File Type
2409246 Vaccine 2007 8 Pages PDF
Abstract

Cell-mediated immune responses to BCG vaccine were evaluated in 7-month-old infants vaccinated with intradermal combined BCG and Hepatitis B or intradermal BCG and intramuscular Hepatitis B at birth. Peripheral blood mononuclear cell cultures from both groups showed CD4+, CD8+ and remarkable γδ+ T cell BCG-specific proliferation, without significant differences. Also, IL-10, IL-12, IFN-γ and TNF-α concentrations in culture supernatants, measured by ELISA, were similar. The results suggested that the combined BCG and Hepatitis B vaccine was as immunogenic as BCG separated from Hepatitis B vaccine.

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Life Sciences Immunology and Microbiology Immunology
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