Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2409246 | Vaccine | 2007 | 8 Pages |
Abstract
Cell-mediated immune responses to BCG vaccine were evaluated in 7-month-old infants vaccinated with intradermal combined BCG and Hepatitis B or intradermal BCG and intramuscular Hepatitis B at birth. Peripheral blood mononuclear cell cultures from both groups showed CD4+, CD8+ and remarkable γδ+ T cell BCG-specific proliferation, without significant differences. Also, IL-10, IL-12, IFN-γ and TNF-α concentrations in culture supernatants, measured by ELISA, were similar. The results suggested that the combined BCG and Hepatitis B vaccine was as immunogenic as BCG separated from Hepatitis B vaccine.
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Authors
T.N. Mazzola, M.T.N. Da Silva, Y.M.F. Moreno, S.C.B.S. Lima, E.F. Carniel, A.M. Morcillo, M.A.R.G.M. Antonio, M.L. Zanolli, A. Aranha Netto, M.H. Blotta, I. Raw, M.M.S. Vilela,