Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2409413 | Vaccine | 2006 | 5 Pages |
Abstract
Various parameters have been examined for the improvement of immune responses induced by immunisation with foot-and-mouth disease virus (FMDV) DNA vaccine (pcDNA 3.1/P1-2A3C3D, P1) in swine. Our findings show that increasing the amount of P1 DNA plasmids and pGMCSF adjuvant plasmids induces stronger FMDV specific and neutralising antibody responses, as well as promoting cytokines IL-8 and IFNγ secretion, in immunised pigs via multiple inoculation sites.
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Authors
Yanmin Li, Neeraj Aggarwal, Haru-H. Takamatsu, Catrina M.A. Sterling, Charlotte Voyce, Paul V. Barnett,