Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2409546 | Vaccine | 2007 | 8 Pages |
Abstract
Humoral and cell-mediated immune responses (CMI) were evaluated in subjects 3 and 6 years after primary and booster vaccination with either three-component acellular (Pa) or whole-cell (Pw) vaccines. Low anti-pertussis toxin (PT) antibody levels confirmed the absence of pertussis disease, consistent with ongoing protection. Anti-pertactin (PRN) antibodies, remained at higher levels in Pa-vaccinated subjects. At year 6, CMI responses continued to be present and were higher in Pa-vaccinated than Pw-vaccinated subjects. Long-term protection with Pa vaccines can be expected to be at least as good as that provided by efficacious Pw vaccines.
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Authors
N. Guiso, E. Njamkepo, F. Vié le Sage, F. Zepp, C.U. Meyer, V. Abitbol, N. Clyti, S. Chevallier,