| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2409559 | Vaccine | 2007 | 6 Pages |
Abstract
Response to hepatitis A and B vaccines has been reported to decline with age. This open, prospective, single-site study examined the long-term response to the combined hepatitis A/B vaccine Twinrix™ in 98 primary responders aged 45–67 years. Levels of antibody against hepatitis A virus (HAV) and hepatitis B surface antigen (HBs) were tested 30 months after initial vaccination. At this stage, all participants remained seropositive for anti-HAV and 70% for anti-HBs. A booster vaccination was offered to those who had responded to the first vaccination but then lost protective levels of anti-HBs. An anamnestic response was observed in all cases.
Keywords
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Immunology and Microbiology
Immunology
Authors
Thomas Höhler, Gudrun Groeger-Bicanic, Bernard Hoet, Michel Stoffel,