Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2409831 | Vaccine | 2007 | 9 Pages |
Abstract
A soluble fraction obtained from Bordetella pertussis was evaluated as adjuvant for the pertussis component of the Diphtheria-Pertussis-Tetanus (DPT) vaccine. High levels of antibodies were induced, and a 78% protection rate of mice challenged with live B. pertussis was observed. Two proteins were identified as the 73 kDa N-terminal α-domain of BrkA autotransporter protein and the Cpn60/60 kDa chaperonin. Both stimulated antibodies against pertussis and induced a 42% protection rate against the challenge. IgG1 and IgG2a were stimulated suggesting that the immune response could be modulated to produce Th1 or Th2.
Keywords
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Authors
Vera C.B. Cainelli Gebara, Luciana Risoléo, Alexandre P.Y. Lopes, Vera R.F. Ferreira, Wagner Quintilio, François Lépine, Wilmar D. Silva, Isaías Raw,