Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2409844 | Vaccine | 2007 | 10 Pages |
Abstract
We have developed recombinant vesicular stomatitis virus (VSV) vectors expressing the Yersinia pestis lcrV gene. These vectors, given intranasally to mice, induced high antibody titers to the LcrV protein and protected against intranasal (pulmonary) challenge with Y. pestis. High-level protection was dependent on using an optimized VSV vector that expressed high levels of the LcrV protein from an lcrV gene placed in the first position in the VSV genome, followed by a single boost. This VSV-based vaccine vector system has potential as a plague vaccine protecting against virulent strains lacking the F1 protein.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Amy Palin, Anasuya Chattopadhyay, Steven Park, Guillaume Delmas, Rema Suresh, Svetlana Senina, David S. Perlin, John K. Rose,