Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2409925 | Vaccine | 2005 | 9 Pages |
Abstract
Apoptosis is considered to be a way of eliminating unwanted cells without causing major inflammation. Nevertheless, several lines of evidence show that apoptotic cell-derived antigens can be strong immunogens. The rabies virus glycoprotein G-ERA is an apoptotic molecule. We tested the ability of G-ERA to potentiate a B cell response against an exogenous antigen (influenza hemagglutinin, HA). We found that co-expression of G-ERA and HA in apoptotic bodies increased both the primary and memory HA-specific immune responses. The immunopotentiation of G-ERA is apoptosis-mediated but not necrosis-mediated. Our data indicate that G-ERA-mediated apoptosis might be useful to improve the immunogenicity of live vaccines.
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Authors
F. Mégret, C. Prehaud, M. Lafage, C. Batejat, N. Escriou, S. Lay, M.I. Thoulouze, M. Lafon,