Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2410138 | Vaccine | 2006 | 8 Pages |
Abstract
Two recombinant antigens which individually protect mice from lethal intranasal infection were studied in combination, either as a mixture of two separately expressed proteins or as a single chimeric expression product. Mice vaccinated with either combination survived longer than mice given single antigens. Immunized mice also exhibited specific IgG immunoglobulins and yielded splenocytes which produced interferon-γ in response to either antigen. The chimeric antigen has the practical advantage of offering enhanced protection from multiple components without increasing production costs.
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Authors
Lisa F. Shubitz, Jieh-Juen Yu, Chiung-Yu Hung, Theo N. Kirkland, Tao Peng, Robert Perrill, Julie Simons, Jianmin Xue, Roger A. Herr, Garry T. Cole, John N. Galgiani,