Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2410646 | Vaccine | 2005 | 9 Pages |
Abstract
DNA vaccination is discussed as having the potential of improving therapy of type I allergies. A mouse model was used to investigate the effect of DNA vaccination against sensitisation with the clinically relevant Phl p 5b major allergen from timothy grass pollen in an immunoprophylactic experimental setup. Pre-treating the mice with Phl p 5b-DNA-construct significantly inhibited the production of specific IgE and IgG1 antibodies and prevented the development of a lung pathology associated with inflammation. Thus, immunoprophylaxis with an expression vector containing the Phl p 5b sequence totally prevented the emergence of characteristics associated with type I allergy and chronic bronchitis.
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Authors
Yasemin Darcan, Arnd Petersen, Wolf-Meinhard Becker, Jürgen Galle, Martin Ernst, Jabbar Ahmed, Ulrike Seitzer,