| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2411010 | Vaccine | 2005 | 5 Pages |
Abstract
DermaVir is a novel topical immunisation designed to target Langerhans cells (LC), the epidermal precursors of dendritic cells. LC serve as a vehicle to process and transfer antigens from the skin to T cell areas in the lymphoid organs. The HIV DNA delivered by DermaVir to LC expresses most viral regulatory and structural genes and induces T cell-mediated immune responses with broad specificity. In chronically infected macaques, DermaVir administered with antiretroviral drugs, suppressed viral load rebound after treatment interruption and improved survival. DermaVir is a promising antiretroviral treatment approach with a unique mechanism of action for combination with currently used drugs.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Franco Lori, Jeffrey Trocio, Nyasha Bakare, Laurene M. Kelly, Julianna Lisziewicz,