Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2411059 | Vaccine | 2005 | 6 Pages |
Abstract
We have investigated the lipid polylysine core peptide (LCP) system as a self-adjuvanting group A streptococcal (GAS) vaccine delivery approach. LCP constructs were synthesised incorporating peptides from the M protein conserved carboxy terminal C-repeat region, the amino terminal type-specific region and from both of these regions. Immunisation with the constructs without adjuvant led to the induction of peptide-specific serum IgG antibody responses, heterologous opsonic antibodies, and complete protection from GAS infection. These data indicate that protective immunity to GAS infection can be evoked using the self-adjuvanting LCP system, and point to the potential application of this system in human mucosal GAS vaccine development.
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Authors
Colleen Olive, K. Hsien, A. Horváth, T. Clair, P. Yarwood, I. Toth, M.F. Good,