Article ID Journal Published Year Pages File Type
2429713 Developmental & Comparative Immunology 2011 10 Pages PDF
Abstract

Four major ancesteral IgL isotypes have been identified κ, λ, σ and σ-cart. However, depending on the vertebrate class the genomic representation of these isotypes differs in regards to what is encoded in the germline and how these genes are organized. Also, the relative contribution of each isotype in immune responses varies. This review focuses on the IgL chains of ectothermic vertebrates, specifically the number of different isotypes, their phylogenetic relationship, genomic organizations and expression.

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Life Sciences Biochemistry, Genetics and Molecular Biology Developmental Biology
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