Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2430063 | Developmental & Comparative Immunology | 2008 | 4 Pages |
SummaryNatural killer T (NKT) cells have been described in the liver and spleen of adult rats, but their presence and function in other tissues and in early life remains uncertain. This study was designed to determine the proportion of NK cells and NKT cells among small intestine intraepithelial (IE) lymphocytes in suckling rats and adult animals by flow cytometry. Very few intestinal IE-NKT cells (NKR-P1A+ TCRαβ+) were present in adult rats (∼1%), but a high proportion of this population was found during early life (∼40% of IE lymphocytes in 9-day-old rats), with a marked age-decreasing pattern. Most of these cells presented the CD8αβ+ phenotype. Intestinal IE-NK cells (NKR-P1A+ TCRαβ−) were also present in a relatively high proportion during the suckling period (∼30% of IE lymphocytes). Thus, a predominance of both NK and NKT cell subpopulations in small intestine epithelium is characteristic in the early life of rats and may have a protective role during the suckling period.