Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2436575 | International Journal for Parasitology | 2006 | 8 Pages |
Abstract
The lung schistosomulum of Schistosoma mansoni is a validated target of protective immunity elicited in vaccinated mice. To identify genes expressed at this stage we constructed a microarray, representing 3088 contigs and singlets, with cDNA derived from in vitro cultured larvae and used it to screen RNA from seven life-cycle stages. Clustering of genes by expression profile across the life cycle revealed a number of membrane, membrane-associated and secreted proteins up-regulated at the lung stage, that may represent potential immune targets. Two promising secreted molecules have homology to antigens with vaccine and/or immunomodulatory potential in other helminths.
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Authors
Gary P. Dillon, Theresa Feltwell, Jason P. Skelton, Peter D. Ashton, Patricia S. Coulson, Michael A Quail, Nefeli Nikolaidou-Katsaridou, R. Alan Wilson, Alasdair C. Ivens,