| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2473253 | Current Opinion in Virology | 2015 | 8 Pages |
Abstract
•Molecular mechanisms of HTLV-1 oncogenesis.•Innate and acquired immune response to HTLV-1.•Clonality of HTLV-1 in vivo.•We bring together the host and viral factors that result in ATL.
A typical person infected with the retrovirus human T-lymphotropic virus type 1 (HTLV-1) carries tens of thousands of clones of HTLV-1-infected T lymphocytes, each clone distinguished by a unique integration site of the provirus in the host genome. However, only 5% of infected people develop the malignant disease adult T cell leukaemia/lymphoma, usually more than 50 years after becoming infected. We review the host and viral factors that cause this aggressive disease.
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Authors
Charles RM Bangham, Lee Ratner,