| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2473441 | Current Opinion in Virology | 2011 | 6 Pages |
The emerging field of paleovirology aims to study the evolutionary age and impact of ancient viruses (paleoviruses) on host biology. Despite a historical emphasis on retroviruses, paleoviral ‘fossils’ have recently been uncovered from a broad swathe of viruses. These viral imprints have upended long-held notions of the age and mutation rate of viruses. While ‘direct’ paleovirology relies on the insertion of viral genes in animal genomes, examination of adaptive changes in host genes that occurred in response to paleoviral infections provides a complementary strategy for making ‘indirect’ paleovirological inferences. Finally, viruses have also impacted host biology by providing genes hosts have domesticated for their own purpose.
► Viral fossils embedded in animal genomes provide unique insight into the evolutionary age and mutation rate of viral lineages. ► Paleoviruses may span the currently known breadth of animal virology. ► Some viral genes have been domesticated by host genomes for housekeeping or defense functions. ► Indirect paleovirology investigates adaptive evolution in host genes to infer the action of an ancient virus.
