| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2473542 | Current Opinion in Virology | 2012 | 6 Pages |
Abstract
► HCMV infect a broad spectrum of cells and entry into different cells involves different receptors, distinct pathways of entry, and the use of different gH/gL complexes: gH/gL and gH/gL/UL128-131. ► Entry into fibroblasts involves direct fusion with the plasma membrane whereas entry into epithelial and endothelial cells involves macropinocytosis followed by low pH-dependent fusion. ► The minimal fusion machinery is gB and gH/gL and these proteins will interact and fuse cells when expressed in apposing cell membranes. ► Previously described HCMV receptors characterized using lab strains do not describe gH/gL/UL128-131 dependent entry into epithelial and endothelial cells.
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Authors
Adam L Vanarsdall, David C Johnson,