| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2473561 | Current Opinion in Virology | 2011 | 7 Pages |
In addition to the essential function of the viral RNA as a template during replication of positive-stranded (+)RNA viruses, the RNA also has crucial non-template functions. These functions during replication include the recruitment of the viral RNA to the site of replication and assembly of the functional viral replicase complex. The RNA recruitment elements are specifically recognized by the viral replication protein, but also affected by host factors such as elongation factor 1A or P-body proteins. The cis-elements for replicase assembly can partially overlap with RNA recruitment elements and they may provide a platform for the assembly of the replicase complex consisting of viral and host proteins. This review focuses on our current knowledge obtained with tombusviruses and other plant viruses. Altogether, understanding of the non-template functions of the viral RNA during viral replication provides new insights into virus–host interactions.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Viral (+)RNA has both template and nontemplate functions during replication. ► Cis-acting elements are involved in viral RNA recruitment. ► Key role of the viral RNA in the assembly of the viral replicase complex. ► Interactions between the viral RNA and viral and host proteins are required during virus replication.
