Complementary therapies for side effects of chemotherapy and radiotherapy in the upper gastrointestinal system

IntroductionChemotherapy and radiotherapy remain the mainstay of treatment for patients with advanced malignant disease that is incurable by local surgery. However, effective use of these therapies is limited by toxic effects. Serious side effects in the upper GI system include mucositis, xerostomia, nausea and vomiting. Standard care for these side effects is suboptimal. Recent studies suggest complementary and alternative medicine (CAM) may have a role in supportive care for people with cancer. We therefore reviewed the literature to assess the potential role of CAM in upper GI toxicities of chemo/radiotherapy.MethodsWe conducted a Medline term-combination search for articles in English that included: stomatitis, mucositis, xerostomia, nausea, vomiting, chemotherapy, radiotherapy, complimentary/alternative therapies, amino acids, antioxidants, vitamins, minerals, plant extracts, herbs, mind–body, guided imagery, hypnosis, acupuncture, massage and yoga.ResultsThe initial search identified a total of 217 articles. Of these, 36 were selected and reviewed. Recommendations for integration of some CAM therapies in supportive cancer care can be made.ConclusionCAM therapies can be effective and safe in treating upper GI toxicities of chemo/radiotherapy. Guidelines in supportive cancer care should include appropriate CAM therapies, and patients need to be informed of such treatment options.