| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2482869 | Free Radicals and Antioxidants | 2013 | 5 Pages |
Abstract
The dual effect of pyruvate might be associated with a metabolic signaling pathway that depends on the oxidizing profile of the target cell. However, the effects of pyruvate must be further studied before using this compound as an anti-inflammatory or anti-oxidant therapeutic resource.
Keywords
PKCRLUAGEsTLRPTPHUVECHO-1HMGB-1GSHPI-3KRAGEsHeme oxygenase-1PBMNCsT2DMConcanavalin AJnkDMEMLPSTLR4c-Jun N-terminal kinaseROSinterleukinCon Ahigh-mobility group box 1Type 2 diabetesdiacylglycerolDAGHuman umbilical vein endothelial cellsperipheral blood mononuclear cellsphosphatidylinositol-3 kinaseLipopolysaccharidesAdvanced glycation end productsDulbecco’s modified eagle’s mediumrelative light unitsprotein tyrosine phosphatasesProtein kinase CPyruvateGranulocytesGlutathioneGlutathione ethyl esterReactive oxygen speciesReceptor for advanced glycation end productsToll-like receptors
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Authors
Jamille Silveira Fernandes Chamon, Fernanda Sarmento Fagundes-Netto, Raquel Miranda Gonzaga, Pollyanna Stephanie Gomes, Caroline Maria de Oliveira Volpe, José Augusto Nogueira-Machado,