Article ID Journal Published Year Pages File Type
2489112 Medical Hypotheses 2013 5 Pages PDF
Abstract

Carcinogenesis is regarded as a mutagenesis, a process of continuous generation of mutations in a cancerous cell. The basis of this process contains a carcinogenic hyper-cycle as one of the forms of the RNA world progress. On the one side, this hyper-cycle ensures self-reproduction, on the other side, generation of mutations of DNA oligo-nucleotides, which, on its part, leads to its re-programming and a cancerous transformation of the cell.Carcinogenic hyper-cycle is generated at the beginning as an autonomous process of RNA replication in the cytoplasm of a cell which has stopped the cooperation with the DNA replication. Under influence of different factors, it gets the ability for concurrence with the DNA replication, becomes a new organizer of the order in the cell, and gradually supersedes and represses the latter one (DNA replication).In the article, the structure of a carcinogenic hyper-cycle is mentioned, factors which lead to its generation and development, and new possibilities of cancer treatment resulting from this.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Developmental Biology
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