| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2489441 | Medical Hypotheses | 2012 | 4 Pages |
Abstract
Recently, there have been increasing evidences that microRNA-146 (miR-146) is related to up-regulated immune and inflammatory signaling through its target genes, such as IRAK1 and TRAF6. Additionally, abundant data continue to support the hypothesis that progressive up-regulation of inflammatory gene expression and elevated inflammatory signaling facilitate the development and progression of Alzheimer’s disease (AD). This review focuses on the recent findings regarding the role of miR-146 in modulating immune response and its subsequent effects in the pathogenesis of AD.
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Authors
Li-Ling Wang, Yue Huang, Gang Wang, Sheng-Di Chen,