| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2490467 | Medical Hypotheses | 2011 | 6 Pages |
Abstract
HLA-G, a very conserved non-classical class I human leukocyte antigen, is highly expressed in cancer pathologies. Recent evidences about HLA-G implication in immune tolerance announce the probable association between HLA-G and metastasis. We highlighted here possible mechanisms for link between HLA-G regulation and cascade metastasis including initiation, progression, and virulence steps. A thorough understanding of HLA-G implications in metastasis through future clinical studies, may probably lead to the improvement of cancer therapies and the limitation of relapses and metastasis.
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Authors
Ines Zidi, Nidhal Ben Amor,