| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2492341 | Medical Hypotheses | 2007 | 4 Pages |
Abstract
SummaryRecently, we have documented that the season of diagnosis affects the prognosis of Hodgkin’s lymphoma, colon-, breast- and prostate-cancer patients in Norway. The relative risk of death was lower for the patients diagnosed during summer and autumn when compared with the winter diagnosis. We here hypothesise that UV (ultraviolet) induced degradation of folate may be the reason for the observed seasonal variations in cancer prognosis. It is known that folic acid, a synthetic form of folate, is degraded by UV radiation. We have also found that the most common folate derivative in the human body, 5-methyltetrahydrofolate, is UV sensitive.
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Authors
Arnfinn Hykkerud Steindal, Alina Carmen Porojnicu, Johan Moan,