| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2493658 | Neuropharmacology | 2011 | 12 Pages |
Abstract
⺠Raloxifene inhibited glutamate release from rat cerebrocortical synaptosomes. ⺠This action was rapid, and did not involve the participation of estrogen receptors. ⺠A decrease in the Ca2+ influx through Cav2.2 and Cav2.1 channels was involved. ⺠A role for the MAPK/ERK pathway in the action of raloxifene was suggested. ⺠This study provided further understanding of the mode of raloxifene action in the brain.
Keywords
GDHHEPES buffer mediumGF109203XCGP371574-APpKaHBMVDCCERKPD98059SERMPKCω-CgTX GVIAKN62H89U0126Fura-2-AM4-aminopyridineBSADiSC3(5)dl-TBOAERK1/2MAPK[Ca2+]cω-agatoxin IVAω-conotoxin GVIAω-conotoxin MVIICbovine serum albuminglutamate releaseBAPTA-AMbisindolylmaleimide ICNSRaloxifenecentral nervous systemSynaptosomesSynapsin Iendoplasmic reticulumcytosolic free Ca2+ concentrationFura-2-acetoxymethyl esterMEKSelective estrogen receptor modulatorprotein kinase AProtein kinase Cmitogen-activated protein kinaseVoltage-dependent Ca2+ channelsVoltage-dependent Ca2+ channelextracellular signal-regulated kinase 1 and 2glutamate dehydrogenase
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Authors
K.L. Hung, C.C. Wang, S.J. Wang,