Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2494086 | Neuropharmacology | 2010 | 8 Pages |
Abstract
This study aimed to examine the feasibility of using thyroid hormone (TH) as a therapeutic agent for Alzheimer's disease (AD). Mice were injected intra-hippocampally aggregated amyloid β-peptide (Aβ) to produce AD animal model. Intraperitoneal administration of l-thyroxine (L-T4) into Aβ-induced AD model mice prevented their cognitive impairment and improved their memory function. The mechanisms of L-T4 treating AD might be associated with regulating cholinergic function, protecting the brains of AD model mice against damage from free radicals, and rescuing hippocampal neurons from apoptosis. The results of the present study indicate that the use of TH has some therapeutic potential in AD.
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Authors
Ai Ling Fu, Cheng Yu Zhou, Xiang Chen,