Antithrombolytic and Antidiabetic Activity of Methanolic Extract of Paederia foetida

Present study was carried out to investigate the antidiabetic and antithrombolytic properties of methanolic extracts of the whole plant of Paederia foetida. Alloxan-induced male Sprague Dawley (SD) rats were given the whole plant extract of methanol by gastric gavage at doses of 250, 500, 1000 mg/kg body wt. and the results of reduction of blood glucose levels were compared with negative control (Tween 80 solution) & positive control (Glibenclamide). Methanolic extracts of the whole plant of P. foetida has moderate antidiabetic activity. At the 3rd hour, the dose of 250, 500 and 1000 mg/kg decreased the blood glucose levels by 31.6%, 28% and 30.3%, respectively, while the reference drug (glibenclamide, 2 mg/kg) decreased the blood glucose level by 70%. 100 µl extract of P. foetida exhibited the highest thrombolytic activity (among three samples) with clot lysis value of 23.82% whereas standard streptokinase (positive control) and water (negative control) demonstrated clot lysis value of 45.85% and 2.81%, respectively.