Cytotoxicity and Antioxidant Activity of New Biologically Active Constituents from Salvia Lanigra and Salvia Splendens

Chromatographic fractionation of the acetone extracts of each of Salvia lanigra and Salvia splendens and of the n-butanol extract of Salvia lanigra, resulted in the isolation and identification of two known diterpenes; horminone (1) and 7-O-ethylhorminone (2), three new diterpenes; salviatane B (3), salvianol A (4) and salviaclerodan A (5), two known triterpenioc acids; ursolic acid (6) and oleanolic acid (7), a known sterol; β-sitosterol (8), two known flavones; salvigenin (9) and apigenin (10) and one new caffiec acid dimmer; 3,3ȃ-dehydrodicaffeic acid (11). The cytotoxicity and the antioxidant activity of the different extracts (MeOH, acetone and n-butanol) of both Salvia lanigra and Salvia splendens and most of the isolated pure compounds (1-5, 9 and 10) were determined.